Psoriasis Shots Include Biologics, Humera, Amevive, and Stelara
Doctors usually administer psoriasis shots as a last resort for patients
who have tried all other forms of treatment for their psoriasis. You
currently cannot get these medicines without a prescription from a
doctor, in part, because injecting yourself carries its own set of risks
and in part because each of the medicines is fairly powerful and can
interact with a whole range of other conditions and drugs.
Up until fairly recently, most shots would have been
synthetically created to target specific parts of your immune
responsible for the buildup of plaque and inflammation. Synthetic
chemicals tend to have more negative side effects than natural medicines
so patients with severe psoriasis tended to avoid them.
advent of biologic medicines has managed to combine natural chemical
reactions with FDA standards for drugs. Live human or animal proteins,
are the components of biologic medicines, such as insulin as an example,
but psoriasis medications target areas of your immune system. They
still carry side effects, which are not as severe as the synthetic
Types of Biologic Drugs
When it comes to
the three main types of biologics are:
Necrosis Factor-Alpha Blockers – Despite the long name, the tumor
necrosis factor-alpha (TNF-alpha) chemical is responsible for
inflammation in your body. While it hurts and can itch, inflammation
helps to increase blood flow to the area so that more anti-bodies and
clotting agents can get to work on healing the area. However, in
psoriasis, this is the chemical that is most often out of balance, so
blocking the receptors helps to reduce levels of TNF-alpha and in turn
reduces the amount of inflammation around the areas of your skin
affected by psoriasis.
- Interleukin Blocker –
Scientists currently think that two main proteins, also called
cytokines, are responsible for the creation of the additional skin cells
that lead to plaque buildup. These are known formally as interleukin-12
and interleukin-23 and any drug that reduces their activity may also
reduce the amount of excess skin produced by your body.
Blocker –Your white blood cells, which are the part of your blood
responsible for killing off infections, viruses and diseases, contain
T-cells, which actively break down the bacteria responsible for making
you ill. Psoriasis sufferers have a genetic default which makes their
T-cells attack their skin instead of leaving it alone, which in turn
causes the inflammation and scaly texture. T-cell blockers stop chemical
signals being sent to your white cells, which can put you at risk of
other diseases, as it will weaken your immune system.
Common Brands of Psoriasis Shots
While many different companies produce psoriasis shots, the most common brands are:
- Humira –
This TNF-alpha blocker drug requires a high initial dosage for the first
week, and then your doctor will follow with weekly injections. It can
take a few weeks to see real results with Humira, but they tend to be
- Stelara –
This injection is the most common interleukin drug and requires minimal
contact with your doctor. You get two injections in the first month,
and then one injection every three months. The side effects feel like
the flu so you will need to carefully monitor your health.
- Amevive –
This is the go-to drug for T-cell blocking and requires a small
injection once a week for 12 weeks. After this initial period, your
doctor will assess your symptoms and you will have to wait 12 weeks
before starting a second round of treatment.
is clear that all the psoriasis shots will affect your immune system,
which is why your doctor will try various other treatments before
initiating a course of injections.
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